This newly reorganized and expanded Second Edition of the revolutionary reference guide, Atopic Dermatitis, is the only available text devoted to discussing all aspects of this common disease. Appealing to dermatologists, allergists, family practitioners, and pediatricians in daily practice, as well as physician scientists, medical students, and experimental investigators, this stand-alone guide addresses recent breakthrough discoveries in genetics and new milestones in immunological research in dermatology. New highlights in the Second Edition:
12 brand new chapters that encompass the latest research
the latest advances, including regulatory and Th17 cells in atopic dermatitis, cytokines and chemokines, virus infections, autoantigens, specific immunotherapy, the immune system and atopic dermatitis, and neuromediators and the pathophysiology of pruritus
coverage of the most recent areas of advancement: pathophysiology, mechanisms and cellular aspects, epidemiologic, genetic, and immunologic aspects of atopic dermatitis

DEFINITION AND GENERAL MECHANISMS OF ATOPIC DERMATITIS
Atopic Dermatitis: One or Several Diseases?
Thomas Bieber
Epidemiology
Carsten Flohr and Hywel C. Williams
Genetics of Atopic Eczema
Stephan Weidinger, Elke Rodriguez, and Alan D. Irvine
Epidermal Barrier in Atopic Dermatitis
Ehrhardt Proksch, Regina F¨olster-Holst, and Jens-Michael Jensen

CELLULAR ASPECTS
Keratinocytes and the Cytokine/Chemokine Orchestra
Bernhard Homey
Innate Immunity in Atopic Dermatitis
Tissa R. Hata and Richard L. Gallo
Role of T cells
Cevdet Ozdemir, M¨ ubeccel Akdis, and Cezmi A. Akdis
Antigen-Presenting Cells
Natalija Novak and Thomas Bieber
Mast Cells and Basophils
Anne-Marie Irani and Lawrence B. Schwartz
Eosinophils
Kristin M. Leiferman, Margot S. Peters, Douglas A. Plager, and Gerald J. Gleich
Pathophysiology of Pruritus
Sonja Stander and Thomas A. Luger

IMMUNOLOGIC TRIGGERS
Role of Aeroallergens in Atopic Eczema: Diagnostic Relevance of the Atopy Patch Test
Ulf Darsow and Johannes Ring
Food Allergens and Atopic Dermatitis
Julie Wang and Hugh A. Sampson
Fungi in Atopic Dermatitis
Peter Schmid-Grendelmeier, Sabine Zeller, and Reto Crameri
Role of Staphylococcus aureus in Atopic Dermatitis
Peck Y. Ong and Donald Y. M. Leung
Virus Infections in Atopic Dermatitis
Natalija Novak and Donald Y. M. Leung

MANAGEMENT
Psychoimmunology and Evaluation of Therapeutic Approaches
Uwe Gieler, Volker Niemeier, Burkhard Brosig, and Bruce G. Bender
Conventional Topical Treatment of Atopic Dermatitis
Mark Boguniewicz
Special Aspects in Pediatrics
Franck Boralevi and Alain Ta¨ıeb
Specific Immunotherapy in Atopic Dermatitis
Thomas Werfel
Ultraviolet Phototherapy and the Management of Atopic Dermatitis
Travis Vandergriff and Heidi Jacobe
Topical Immunomodulators: Topical Calcineurin-Inhibitors
Thomas A. Luger and Martin Steinhoff
Systemic Pharmacotherapy
Werner Aberer, Klaus Wolff, and Thomas Bieber