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These 20 papers represent the state of current research concerning the use of transgenic technology in endocrinological applications, including its use in the study of sexual differentiation, steroidgenesis, skeletal biology, prostate cancer, ovarian function, insulin, and obesity. The book reviews recent developments in the analysis of endocrine physiology and its pathologies, especially through mouse models. Contributors include medical researchers from the United States, Europe, Australia, and Japan.

Book Info

Baylor College of Medicine, Houston, TX. Features a review of transgenic techniques to study endocrine gland development and function, examples of the power of transgenic technology to explain endocrine disorders, applications to a broad range of topics, and knowledge and experience of leading researchers.

Preface
Contributors
1 Germline Genetic Engineering Techniques in Endocrinology 1
2 The Transgenic Mouse in Studies of Mammalian Sexual Differentiation 19
3 The In Vivo Function of Mullerian-Inhibiting Substance During Mammalian Sexual Development 41
4 Control of Ovarian Function 61
5 Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression 91
6 Functional Analysis of the Bcl2 Gene Family in Transgenic Mice 115
7 The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis 147
8 Gene Knockout Approaches to Steroidogenesis 165
9 The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo 173
10 Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development 205
11 Prolactin and the Prolactin Receptor 231
12 Transgenic Models for Oxytocin and Vasopressin 245
13 Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function 261
14 Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation 297
15 Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System 319
16 Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity 339
17 Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors 371
18 Use of Transgenic Animals in Skeleton Biology 385
19 Transgenic Mouse Models of Prostate Cancer 401
20 Neural- and Endocrine-Cell Specific Immortalization Using Transgenic Approaches 427
Index 469