Pancreatic cancer remains to be a challenge for the health care providers in the world. For the past three decades, we have made few breakthroughs for managing this malignant disease. Unless a breakthrough would be made in the near future, as projected, pancreatic cancer would become the second leading cause of death from cancer diseases in the United States by 2020. The contributions of the clinicians and clinical researches to the field of pancreatic cancer have revolutionized the entire medicine and surgery field. Many chapters of this book have testified the importance of the advancements in the management of pancreatic cancer as landmarks in the history of medicine and surgery.