Turn to the field's most trusted text for a complete understanding of the principles of biochemistry and molecular biology as they relate to modern medicine>

Clear, concise, and now in full-color, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.

The Twenty-Eighth Edition has undergone sweeping changes - including a conversion to full-color artwork and every chapter being substantially revised and updated - all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.

Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic.

NEW to this edition:


Every chapter now begins with a Summary of the Biomedical Importance of its contents and concludes with a Summary reviewing the topics covered
Two all-new chapters: Free Radicals and Antioxidant Nutrients and Biochemical Case Histories which offers an extensive presentation of 16 pathophysical conditions
An Expanded Appendix containing a list of important biochemistry websites, data bases, and online journals
NEW or updated coverage of important topics such as: The influence of the Human Genome Project on the; biomedical fields; Computer-aided drug delivery; The attachment of influenza virus to human cells; Next Generation Gene Sequencing platforms; Methods of assaying enzymes; Advanced glycation end-products and their importance in diabetes mellitus; The major challenges facing medicine

Biographical note
David A. Bender, PhD,
Sub-Dean University College Medical School,
Senior Lecturer in Biochemistry,
Department of Structural and Molecular Biology and
Division of Medical Education,
University College London

Kathleen M. Botham, PhD, DSc,
Professor of Biochemistry, Royal Veterinary
College, University of London

Daryl K. Granner, MD,
Emeritus Professor of Molecular Physiology and Biophysics
and Medicine,
Vanderbilt University, Nashville, Tennessee

Peter L. Gross MD, MSc, FRCP(C),
Associate Professor, Department of Medicine,
McMaster University

Frederick W. Keeley, PhD,
Associate Director and Senior Scientist, Research Institute,
Hospital for Sick Children, Toronto, and Professor,
Department of Biochemistry, University of Toronto

Peter J. Kennelly, PhD,
Professor and Head, Department of Biochemistry,
Virginia Polytechnic Institute and State University,
Blacksburg, Virginia

Robert K. Murray, MD, PhD,
Professor (Emeritus) of Biochemistry,
University of Toronto

Margaret L. Rand, PhD,
Associate Senior Scientist, Hospital for Sick Children, Toronto,
and Professor, Departments of Laboratory Medicine and Pathobiology
and Department of Biochemistry, University of Toronto

Victor W. Rodwell, PhD,
Emeritus Professor of Biochemistry, Purdue University, West Lafayette,
Indiana

P. Anthony Weil, PhD,
Professor of Molecular Physiology and Biophysics,
Vanderbilt University School of Medicine,
Nashville, Tennessee

1. Biochemistry and Medicine
2. Water & PH
3. Amino Acids and Peptides
4. Proteins: Determination of Primary Structure
5. Proteins: Higher Orders of Structure
6. Proteins: Myoglobin and Hemoglobin
7. Enzymes: Mechanisms of Action
8. Enzymes: Kinetics
9. Enzymes: Regulation of Activities
10. Bioenergetics: The Role of ATP
11. Biologic Oxidation
12. The Respiratory Chain & Oxidative Phosphorylation
13. Carbohydrates of Physiologic Significance
14. lipids of Physiologic Significance
15. Overview of Metabolism
16. The Citric acid Cycle: The Catabolism of Acetyl-CoA
17. Glycolysis and Oxidation of Pyruvate
18. Metabolism of Glycogen
19. Gluconeogenesis and Control of the Blood Glucose
20. The Pentose Phosphate Pathway & other Pathways of Hexose Metabolism
21. Biosynthesis of Fatty Acids
22. Oxidation of Fatty Acids: Ketogenesis
23. Metabolism of Unsaturated Fatty Acids & Eicosanoids
24. Metabolism of Acyglycerols and Sphingolipids
25. Lipid Transport And Storage
26. Cholesterol Synthesis, Transport and Excretion
27. Integration of Metabolism- the Provision of Metabolic Fuels
28. Biosynthesis of Nutritionally Nonessential Amino Acids
29. Catabolism of Proteins & of Amino Acid Nitrogen
30. Catabolism of the Carbon Skeletons of Amino Acids
31. Conversion of Amino Acids
32. Porphyrins & Bile Pigments
33. Nucleotides
34. Metabolism of Purine & Pyrimidine Nucleotides
35. Nucleic Acid Structure and Function
36. DNA Organization, Replication and Repair
37. RNA Synthesis, Processing and Modifications
38. Protein Synthesis and Genetic Code
39. Regulation of Gene Expression
40. Molecular Genetics, Recombinant DNE and Genomic Technology
41. Membranes: Structure and Function
42. The Diversity of Endocrine System
43. Hormone Action and Signal Transduction
44. Nutrition, Digestion and Absorption
45. Vitamins and Minerals
46. Intracellular Traffic and Sorting of Proteins
47. Glycoprotein
48. The Extracellular Matrix
49. Muscle and the Cytoskeleton
50. Plasma Proteins and Immunoglobulins
51. Homeostasis and Thrombosis
52. The Red and White Blood Cells
53. Metabolism of Xenobiotics
54. The Human Genome Project