--- Description ---

Well-known for its authoritative and comprehensive coverage, complete treatment of pediatric pathophysiology, and the most extensive illustration program in its field, this textbook features expert content on everything from the general principles of pathophysiology to detailed discussions of genetics and specific diseases. Chapters on alteration present the pathophysiology, clinical manifestations, and evaluation and treatment of each disease to help you learn to identify normal anatomy and physiology, as well as alterations of function in adults and in children.

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Unparalleled coverage of disease processes makes this text the most comprehensive pathophysiology text available.
The largest full-color art program in the field illustrates the clinical manifestations of diseases and disease processes
Consistent presentations of each disease with pathophysiology, clinical manifestations, and evaluation and treatment help you find the information you need quickly and easily.
Ten separate pediatric chapters cover the pathophysiologic effects on children.
Aging content is highlighted throughout the text.
An Introduction to Pathophysiology section at the beginning of the text provides a solid start to the basics of the study of disease.
Algorithms and flowcharts of diseases and disorders illustrate the disease process in an easy-to-understand format.
Nutrition and Disease boxes present evidence-based information on the relationship between health promotion through diet and disease.

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Updated content on leukocytes in pain modulation, seizure disorders, brain injuries and disorders, acute encephalopathies, reproductive disorders, and much more keep you at the cutting edge of this constantly changing field.
What’s New? boxes highlight the most current research and findings to ensure you have the most up-to-date information.
New animations, review questions, Key Points, and an audio glossary have been added to the Evolve companion website to strengthen your understanding of key concepts.
Media Resources Lists encourage you to develop a study plan to master the important content in each chapter.

--- Companion Products ---

Study Guide for Pathophysiology, 6th Edition : The Biological Basis for Disease in Adults and Children
Pathophysiology Online for Pathophysiology (User Guide and Access Code), 6th Edition : The Biologic Basis for Disease in Adults and Children
Pathophysiology - Text and E-Book Package, 6th Edition : The Biologic Basis for Disease in Adults and Children
Pathophysiology Online for Pathophysiology (User Guide, Access Code and Textbook Package), 6th Edition : The Biologic Basis for Disease in Adults and Children
Pathophysiology - Text and Study Guide Package, 6th Edition : The Biologic Basis for Disease in Adults and Children

--- Related Titles ---

Mosby's Pathophysiology Memory NoteCards : Visual, Mnemonic, and Memory Aids for Nurses

--- Author Information ---

By Kathryn L. McCance, RN, PhD, Professor, College of Nursing, University of Utah, Salt Lake City, UT and Sue E. Huether, RN, PhD, Professor Emeritus, College of Nursing, University of Utah, Salt Lake City, UT

Introduction to Pathophysiology

PART ONE: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES

Unit I: The Cell
Cellular Biology
Altered Cellular and Tissue Biology
The Cellular Environment: Fluids and Electrolytes, Acids and Bases

Unit II: Genes and Gene-Environment Interaction
Genes and Genetic Diseases
Genes, Environment, Life-style, and Common Diseases

Unit III: Mechanisms of Self-Defense
Innate Immunity: Inflammation
Adaptive Immunity
Alterations in Immunity and Inflammation
Infection
Stress and Disease

Unit IV: Cellular Proliferation: Cancer
Biology, Clinical Manifestations, and Treatment of Cancer
Cancer Epidemiology
Cancer in Children

PART TWO: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS

Unit V: The Neurologic System
Structure and Function of the Neurologic System
Pain, Temperature Regulation, Sleep, and Sensory Function
Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function
Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
Alterations of Neurologic Function in Children

Unit VI: The Endocrine System
Mechanisms of Hormonal Regulation
Alterations of Hormonal Regulation

Unit VII: The Reproductive Systems
Structure and Function of the Reproductive Systems
Alterations of the Reproductive Systems
Sexually Transmitted Infections

Unit VIII: The Hematologic System
Structure and Function of the Hematologic System
Alterations of Erythrocyte Function
Alterations of Leukocyte, Lymphoid, and Hemostatic Function
Alterations of Hematologic Function in Children

Unit IX: The Cardiovascular and Lymphatic Systems
Structure and Function of the Cardiovascular and Lymphatic Systems
Alterations of Cardiovascular Function
Alterations of Cardiovascular Function in Children

Unit X: The Pulmonary System
Structure and Function of the Pulmonary System
Alterations of Pulmonary Function
Alterations of Pulmonary Function in Children

Unit XI: The Renal and Urologic System
Structure and Function of the Renal and Urologic Systems
Alterations of Renal and Urinary Tract Function
Alterations of Renal and Urinary Tract Function in Children

Unit XII: The Digestive System
Structure and Function of the Digestive System
Alterations of Digestive Function
Alterations of Digestive Function in Children

Unit XIII: The Musculoskeletal System
Structure and Function of the Musculoskeletal System
Alterations of Musculoskeletal Function
Alterations of Musculoskeletal Function in Children

Unit XIV: The Integumentary System
Structure, Function, and Disorders of the Integument
Alterations of the Integument in Children

Unit XV: Multiple Interacting Systems
Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children