Hardcover - 752 pages


Thoroughly updated for its Second Edition, this volume is the most comprehensive,

current reference on perioperative transfusion medicine and coagulation. It provides

complete information on all current blood products and transfusion risks, transfusion

and coagulation issues during the preoperative, intraoperative, and postoperative periods,

and specific concerns in each surgical subspecialty. Eighteen new chapters in this edition

cover blood shortages, economic concerns, emergency needs, virus transmission, parasitic

and septic risks, immunosuppression risks, non-infectious risks, production and storage

issues, hemoglobin-based oxygen-carrying solutions, perfluorocarbon-based oxygen-carrying

solutions, preoperative plateletphoresis, volume resuscitation, antifibrinolytics,

aprotinin, DDAVP, platelet inhibitors, burn patients, and post-surgical stress response

1 A history of transfusion 3
2 The contemporary economics of transfusions 13
3 Blood supplies now and in the future 39
4 Medical ethics, transfusion, and the standard of practice 45
5 Oxygen transport monitoring : the basis for developing transfusion triggers 55
6 Physiology of anemia and red blood cell transfusion 67
7 Physiology of hemostasis 77
8 Platelet physiology : cellular and protein interactions 93
9 Iron metabolism and erythopoiesis 103
10 New concepts in oxygen transport 117
11 Infectious risks of transfusion 131
12 Immunomodulation by transfusion 153
13 Serious acute transfusion reactions 169
14 A surgeon''s guide to blood banking and transfusion medicine 179
15 Blood storage 199
16 Quality control and hospital blood utilization 211
17 Preoperative autologous donation 223
18 Erythropoietin therapy 241
19 Hemoglobin-based oxygen carriers 253
20 Perfluorocarbon emulsions : artificial gas transport media 273
21 Initial resuscitation of the hemorrhaging patient 289
22 Transfusion and coagulation therapy in trauma and burns 301
23 Acute gastrointestinal bleeding and transfusion management 319
24 Coagulation in trauma : dilution and massive transfusion 329
25 Coagulation product use in the perioperative period 339
26 Perioperative coagulation monitoring 347
27 Surgery in patients with acquired platelet and clotting deficiencies 369
28 Surgery in patients with congenital clotting deficiencies 377
29 Perioperative implications of anticoagulant and antiplatelet therapy 389
30 Pharmacological approaches to prevent or decrease bleeding in surgical patients 403
31 Fibrin glue and platelet gel 419
32 Anesthesia techniques in blood conservation 435
33 Perioperative red cell salvage and autotransfusion 451
34 Intraoperative acute nomovolemic hemodilution 465
35 Hypothermia and hemorrhage 481
36 Surgery in patients with red cell disorders : sickle hemoglobinopathies, polycythemia, and autoimmune hemolytic anemia 489
37 Surgery in the Jehovah''s Witness 503
38 Coagulation, transfusion, and cardiac surgery 513
39 Blood loss and transfusion alternatives in vascular surgery 557
40 Solid organ transplantation 573
41 Blood use in orthopedic surgery 583
42 Blood management in obstetrics and gynecology 597
43 Hemorrhage in pediatric patients 609
44 Transfusion in oncologic surgery 615
45 Transfusion and coagulation dysfunction in neurosurgery 625
46 Transfusion and outcome 645
47 The transfusion decision 659
48 Undertransfusion 667
49 A philosophy of blood management 671