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Providing a foundation in virology and explaining its relationship to modern biology, this introductory textbook emphasizes the basic concepts of molecular biology and immunology. Particular attention is given to the basic properties of viruses, virus-cell interactions, research practices, and replication patterns of specific viruses. Wagner teaches biology at the University of California, Irvine. Hewlett taught molecular and cellular biology at the University of Arizona.

Book Info

Univ. of California, Irvine. Introductory textbook provides a solid foundation in virology and its relationship to modern biology. Focuses on the fundamentals and stresses the basic concepts of molecular biology and immunology. Provides updated material on HIV treatment, West Nile virus, smallpox, and bioterrorism.

Preface
Acknowledgments
Pt. I Virology and Viral Disease 1
Ch. 1 Introduction - The Impact of Viruses on Our View of Life 3
Ch. 2 An Outline of Virus Replication and Viral Pathogenesis 11
Ch. 3 Virus Disease in Populations and Individual Animals 21
Ch. 4 Patterns of Some Viral Diseases of Humans 36
Pt. II Basic Properties of Viruses and Virus-Cell Interaction 49
Ch. 5 Virus Structure and Classification 51
Ch. 6 The Beginning and End of the Virus Replication Cycle 60
Ch. 7 Host Immune Response to Viral Infection: The Nature of the Vertebrate Immune Response 77
Ch. 8 Strategies to Protect Against and Combat Viral Infection 96
Pt. III Working with Virus 117
Ch. 9 Visualization and Enumeration of Virus Particles 119
Ch. 10 Replicating and Measuring Biological Activity of Viruses 127
Ch. 11 Physical and Chemical Manipulation of the Structural Components of Viruses 144
Ch. 12 Characterization of Viral Products Expressed in the Infected Cell 165
Ch. 13 Viruses Use Cellular Processes to Express Their Genetic Information 185
Ch. 14 The Molecular Genetics of Viruses 207
Pt. IV Replication Patterns of Specific Viruses 229
Ch. 15 Replication of Positive-Sense RNA Viruses 231
Ch. 16 Replication Strategies of RNA Viruses Requiring RNA-directed mRNA Transcription as the First Step in Viral Gene Expression 257
Ch. 17 Replication Strategies of Small and Medium-sized DNA Viruses 286
Ch. 18 Replication of Some Nuclear Replicating Eukaryotic DNA Viruses with Large Genomes 311
Ch. 19 Replication of Cytoplasmic DNA Viruses and "Large" Bacteriophages 336
Ch. 20 Retroviruses: Converting RNA to DNA 356
Ch. 21 Hepadnaviruses: Variations on the Retrovirus Theme 377
Ch. 22 Viruses and the Future - Promises and Problems 383
Technical Glossary 409
Index 428