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Offers step-by-step techniques for experimentally detecting Simian Virus 40 (SV40) in human tumors, for exploiting its use in human gene therapy, and for studying its replication and its mechanisms of neoplastic transformation. Included are methods for growing SV40 and its related viruses in tissue culture, for in vivo and in vitro replication and transcription of SV40 DNA, for the use of retroviral vectors to express SV40 tumor antigens in cultured cells, and for transgenic mouse models based on the SV40 large T antigen. An appendix lists suppliers. Raptis is affiliated with Queen's University, Canada.

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Queen's Univ., Kingston, Ontario, Canada. Offers readily reproducible methods for SV40 work and covers replication, gene therapy, detection in tumors, and expression using vectors. For basic and clinical investigators. DNLM: Polyomavirus macacae-genetics.