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In this updated second edition, experts in chemistry, cell biology, neurology, and biopharmaceuticals describe techniques for studying neuronal cell death in step-by-step detail. These reproducible methods solve research problems surrounding the detection of key proteins involved in neuronal apoptosis, the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also methods presented for the study of apoptosis mechanisms in neuronal compartments, for studying synapsosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays. Each protocol includes tips on avoiding pitfalls and notes on advantages and disadvantages. LeBlanc is affiliated with McGill University.Book News, Inc.

Book Info

McGill Univ., Montreal, Canada. Offers cutting-edge protocols to investigate apoptosis in neurons, methods to detect key proteins involved in neuronal apoptosis, techniques to study synaptosis and detect proapoptotic proteins in situ, and notes on the pitfalls and advantages of each method.