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Neuroglia in the Aging Brain |
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From Book News, Inc.
Selections review the current knowledge of the supporting structure of the nervous system, the neuroglia, in aging. The contributors (researchers from North America and Europe) discuss the role of glial cells in normal as well as pathological aging, i.e. in Alzheimer's and Parkinson's disease. Sections cover cellular and molecular changes of aged and reactive astrocytes; neuron-glia intercommunication; neurotrophins, growth factors, and neurohormones in aging and regeneration; metabolic changes; astrocytes and the blood-brain barrier in aging; and astrocytes in neurodegenerative disorders.Book News, Inc.
Book Info
Univ. of California, Los Angeles Mental Retardation Research Center. Discusses the role of glial cells in normal aging and in pathological aging, i.e, neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Covers cellular and molecular changes of aged and reactive astrocytes, and more. DNLM: Brain--cytology.
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Foreword Preface Contributors Pt. I Cellular and Molecular Changes of Aged and Reactive Astrocytes 1 Neuromorphological Changes in Neuronal and Neuroglial Populations of the Cerebral Cortex in the Aging Rat: Neurochemical Correlations 3 2 Diversity in Reactive Astrocytes 17 3 Astrocytic Reaction After Traumatic Brain Injury 35 Pt. II Neuron-Glia Intercommunication 4 Astrocytes In Situ Exhibit Functional Neurotransmitter Receptors 59 5 Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain 77 6 Intercellular Diffusional Coupling between Glial Cells in Slices from the Striatum 99 7 Glial Cell Involvement in Brain Repair and the Effects of Aging 113 8 ATP Signaling in Schwann Cells 135 Pt. III Neurotrophins, Growth Factors, and Neurohormones in Aging and Regeneration 9 Gliosis Growth Factors in the Adult and Aging Rat Brain 157 10 Role of Fibroblast Growth Factor-2 in Astrogliosis 179 11 Trophins as Mediators of Astrocyte Effects in the Aging and Regenerating Brain 199 12 Responses in the Basal Forebrain Cholinergic System to Aging 217 13 Effects of Estrogens and Thyroid Hormone on Development and Aging of Astrocytes and Oligodendrocytes 245 Pt. IV Metabolic Changes 14 Neurotoxic Injury and Astrocytes 259 15 Ammonium Ion Transport in Astrocytes: Functional Implications 275 Pt. V Astrocytes and the Blood-Brain Barrier in Aging 16 Molecular Anatomy of the Blood-Brain Barrier in Development and Aging 291 17 The Blood-Brain Barrier in the Aging Brain 305 18 Astrocytes and Barrier-provided Microvasculature in the Developing Brain 321 Pt. VI Astrocytes in Neurodegenerative Diseases 19 Microglial and Astrocytic Reactions in Alzheimer's Disease 339 20 Activated Neuroglia in Alzheimer's Disease 365 21 Reactive Astroglia in the Ataxic Form of Creutzfeldt-Jakob Disease: Cytology and Organization in the Cerebellar Cortex 375 22 Ischemic Injury, Astrocytes, and the Aging Brain 393 23 Glial-Neuronal Interactions during Oxidative Stress: Implications for Parkinson's Disease 407 24 Astrocytic Changes Associated with Epileptic Seizures 421 25 Synaptic and Neuroglial Pathobiology in Acute and Chronic Neurological Disorders 443 26 Astrocytes and Ammonia in Hepatic Encephalopathy 477 Index 497 |
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