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Researchers active in the field review recent advances in the treatment of various infections, particularly HIV, by manipulation of the immune system's response rather than by using chemical drugs. They summarize principles of immune defense on the molecular level as well as on the cellular and clinical levels as a protection against infection, and describe research in HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function. Also discussed are immunotherapy for other viral infections, virus- associated malignancies, and fungal infections. Jacobson is affiliated with the AIDS Center of the Mount Sinai School of Medicine.Book News, Inc.

Book Info

Mount Sinai School of Medicine, New York City, NY. Provides an overview of the basic principles of immune defense, discusses the principles of immunotherapy on a molecular level, and reviews the current state of anti-HIV immunotherapy. Also review immunotherapy for additional infections and virus-associated malignancies. DNLM: Communicable Diseases-therapy

Preface
List of Contributors
I Basic Principles of Immunity
1 Humoral Immunity 3
2 Some Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious Diseases 23
3 Immune Defense at Mucosal Surfaces 39
II Molecular Basis for Immunotherapy
4 Production of Immunoglobulins and Monoclonal Antibodies Targeting Infectious Diseases 63
5 Dendritic Cells: Their Role in the Immune Response to Infectious Organisms and Their Potential Use in Therapeutic Vaccination 99
6 Cytokines, Cytokine Antagonists, and Growth Factors for Treating Infections 117
7 Principles of Vaccine Development 129
III Immunotherapy for HIV Infection
8 Immunopathogenesis of HIV Infection 151
9 Immune Reconstitution with Antiretroviral Chemotherapy 163
10 Active Immunization as Therapy for HIV Infection 181
11 Passive Immunotherapy for HIV Infection 199
12 Host Cell-Directed Approaches for Treating HIV and Restoring Immune Function 221
13 Gene Therapy for HIV-1 Infection 237
IV Immunotherapy for Infectious Diseases Other than HIV
14 Immunotherapy for Viral Infections Other than HIV 251
15 Immunotherapy for Virus-Associated Malignancies 259
16 Immunotherapy of Bacterial Infections and Sepsis 275
17 Immunotherapy for Tuberculosis and Other Mycobacterial Infections 283
18 Immunotherapy for Fungal Infections 303
Index 323