From Book News, Inc.
Anticipating the single-sock-out-of-the-dryer problem, cells often find that after they have divided, they have lost many bases of DNA due to a shortening of chromosomes. The enzyme telomerase is a mechanism to ensure chromosome stability in both normal and neoplastic cells. Here scientists in cancer research and other fields describe laboratory protocols for investigating the enzyme and its action, both for basic science and for applications in drug discovery. No applications are yet foreseen for the laundry room.Book News, Inc., Portland, OR

Book Info
Univ. of Bradford, UK. Covers a range of novel and essential telomerase assay protocols in step-by-step fashion. Allows the researcher to identify and analyze telomeres, to determine telomerase expression at the RNA level. DNLM: Telomerase--Laboratory manuals.

Book Description
John A. Double and Michael J. Thompson have collected a critically important series of novel and essential techniques for studying telomeres and telomerase. These readily reproducible methods provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to nonradioactive methods, from non PCR-based methods to techniques using real-time PCR. Telomeres and Telomerase: Methods and Protocols provides the core array of productive techniques needed today to develop telomerase inhibitors or diagnostic prognostic telomerase markers.