From Book News, Inc.
The advance in transgenic technologies to express cloned genes in the mouse have led to the mouse becoming one of the most used animal models for biomedical research. Hofker (Maastricht U., The Netherlands) and van Deursen (Mayo Clinic, US) present 18 papers that explain the reasons for picking particular protocols and then describe the protocols in a step-by-step manner. In addition, two chapters describe alternative strategies (random mutagenesis and viral gene transduction) for studying gene function in the mouse. Other topics include generating conditional mouse mutants via tetracycline- controlled gene expression, manipulating large insert clones for transgenesis, reporter molecules in genetically engineered mice, and aggregation of embryos and embryonic stem cells.Book News, Inc., Portland, OR

Book Info
The second author is with the Mayo Clinic, Rochester, MN. Covers the production and analysis of transgenic and knockout mice. Includes a review of mouse models for a wide range of genetic aberrations associated with human disease. Features basic technology and up-to-date methods for conditional and inducible gene expressions.