Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, and the potential new discoveries hold to improve our understanding of cancer epigenetics and therapeutics. The book encompasses both large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically. Increasing evidence links pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

1. Introduction

Part 1: Introduction and Key Concepts
2. DNA Methylation and Hydroxymethylation in Cancer
3. Writers, Readers, and Erasers of Epigenetic Marks
4. Oncohistones
5. MicroRNAs, epi-miRNAs and Cancer
6. Long Noncoding RNAs and Cancer
7. The Epitranscriptome
8. Mining the Epigenetic Landscape: Surface Mining or Deep Underground - Alecsandar Milosavljevic
9: Epigenetics Clocks: Concepts for Carcinogenesis10: Environmental Pollution Epigenetics and Cancer

Part 2: Epigenetics and Cancer
11. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality
12. Epigenetic Therapy in Lung Cancer
13. Breast Cancer Epigenetics
14. Therapeutic Applications of the Prostate Cancer Epigenome
15. Neuroblastoma

Part 3: Targeting Aberrant Epigenetics
16. Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches -
17. Emerging Epigenetic Therapies- Lysine Methyltransferase/PRC Complex Inhibitors
18. Inhibitors of Jumonji C-Domain Histone Demethylases
19. Emerging Epigenetic Therapies: Lysine Acetyltransferase Inhibitors
20: Histone Deacetylases
21. Emerging Epigenetic Therapies

Part 4: Issues to Overcome/Areas of Concern
22. Genetic Intratumoral Heterogeneity
23. Challenges for single cell epigenetic analysis
24. Epigenetics Underpinning DNA Damage Repair
25. Epigenetics of Cisplatin Resistance
26. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells

Part 5: Future Directions: Translation to the Clinic
27. Personalized Epigenetic Therapy-Chemosensitivity Testing
28. Personalized Therapy-Epigenetic Profiling as Predictors of Prognosis and Response
29. Epigenetic Priming - Fact or Fallacy
30. CRISPR and epigenetics
31. Epigenetics and CAR-T