This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Spleen, 2nd Edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.

Key Features
Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses.

Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms.

Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis.

Includes 14 new chapters covering topics such autoimmune disease involving the spleen, COVID-19-related diseases, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, primary splenic mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many more.

Includes approximately 2,000 high-quality clinical and histological images, gross pathology images, radiologic images, and full-color drawings to help practicing and in-training pathologists reach a confident diagnosis.

Includes updated criteria, terminology, and classifications from the 2017 WHO Classification of Lymphoid Neoplasms.

Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care.

Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices.


Author Information
By Aaron Auerbach, MD, MPH, Senior Hematopathologist, Joint Pathology Center, Silver Spring, Maryland and Nadine Aguilera, MD, Professor, Department of Pathology, Section Head, Hematopathology, University of Virginia Health System, Charlottesville, Virginia.

SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN

NORMAL HISTOLOGY

4 Introduction to Spleen
Mohammad A. Vasef, MD
12 Imaging of Splenic Disorders
Mohammad A. Vasef, MD
16 Handling, Processing, and Gross Pathology of Spleen
Mohammad A. Vasef, MD
24 Fine-Needle Aspiration and Core Biopsy of Spleen
Mohammad A. Vasef, MD
30 Immunohistochemistry of Spleen
Aaron Auerbach, MD, MPH
34 Flow Cytometry
Nadine Aguilera, MD
38 Molecular Techniques
Nadine Aguilera, MD

LYMPHOID HYPERPLASIA

44 Florid Follicular Hyperplasia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH
46 Autoimmune Disease
Nadine Aguilera, MD
52 HIV in Spleen
Nadine Aguilera, MD
58 Castleman Disease
Nadine Aguilera, MD
60 Marginal Zone Hyperplasia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH

GRANULOMATOUS LESIONS/DISORDERS

62 Lipogranulomas
Jeffrey Vos, MD
68 Sarcoidosis
Ellina Hall, DO and Aaron Auerbach, MD, MPH
72 Chronic Granulomatous Disease
Aaron Auerbach, MD, MPH

INFECTIONS

76 Splenic Abscesses
Aaron Auerbach, MD, MPH
80 Mycobacteriosis
Nadine Aguilera, MD
84 Selected Bacterial Infections
Aaron Auerbach, MD, MPH
88 Candidiasis
Aaron Auerbach, MD, MPH
90 Histoplasmosis
Nadine Aguilera, MD
92 Cryptococcosis
Nadine Aguilera, MD
94 Coccidioidomycosis
Aaron Auerbach, MD, MPH
98 Pneumocystosis
Aaron Auerbach, MD, MPH
102 Infectious Mononucleosis
Nadine Aguilera, MD
106 Cytomegalovirus Infection
Nadine Aguilera, MD
108 Viral Changes
Nadine Aguilera, MD
112 Herpes Simplex Virus Infection
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD
114 Echinococcosis
Aaron Auerbach, MD, MPH
118 Malaria
Nadine Aguilera, MD

NONINFECTIOUS CYSTS

120 Epithelial Cyst
Ellina Hall, DO and Aaron Auerbach, MD, MPH
122 False Cyst
Ellina Hall, DO and Aaron Auerbach, MD, MPH

NONNEOPLASTIC VASCULAR PROCESSES

124 Chronic Passive Congestion
Ellina Hall, DO and Aaron Auerbach, MD, MPH

126 Infarct
Jeffrey Vos, MD


134 Peliosis
Ellina Hall, DO and Aaron Auerbach, MD, MPH

136 Sclerosing Angiomatoid Nodular Transformation
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

RED CELL DISORDERS

142 Sickle Cell Disease

144 Ellina Hall, DO and Aaron Auerbach, MD, MPH
Thalassemia

148 Nadine Aguilera, MD and Aaron Auerbach, MD, MPH
Hereditary Spherocytosis

150 Nadine Aguilera, MD
Thrombotic Thrombocytopenic Purpura
Aaron Auerbach, MD, MPH


MISCELLANEOUS LESIONS/DISORDERS
156 Heterotaxy Syndromes
Aaron Auerbach, MD, MPH
158 Congenital Splenic Abnormalities
Nadine Aguilera, MD
162 Extramedullary Hematopoiesis
Ellina Hall, DO and Aaron Auerbach, MD, MPH
164 Gamna-Gandy Bodies
Nadine Aguilera, MD
166 Hemophagocytic Syndrome
Nadine Aguilera, MD
168 Idiopathic Thrombocytopenic Purpura
Ellina Hall, DO and Aaron Auerbach, MD, MPH
172 Niemann-Pick Disease
Meenakshi A. Nandedkar, MD
178 Gaucher Disease
Meenakshi A. Nandedkar, MD
182 Sea-Blue (Ceroid) Histiocytosis
Mohammad A. Vasef, MD
186 Tay-Sachs Disease
Mohammad A. Vasef, MD
190 Therapy Effect on Spleen
Aaron Auerbach, MD, MPH
198 Traumatic and Nontraumatic Splenic Injuries
Mohammad A. Vasef, MD

BENIGN MESENCHYMAL LESIONS
204 Vascular Lesions
Nadine Aguilera, MD
206 Hemangioma
Nadine Aguilera, MD
212 Lymphangioma
Nadine Aguilera, MD
216 Littoral Cell Angioma
Nadine Aguilera, MD
222 Inflammatory Pseudotumor
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
230 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
236 Splenic Hamartoma
Nadine Aguilera, MD

240 Myelolipoma
Aaron Auerbach, MD, MPH

MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS

242 Angiosarcoma
Nadine Aguilera, MD
248 Hemangioendothelioma
Nadine Aguilera, MD
250 Kaposi Sarcoma
Nadine Aguilera, MD
252 Leiomyosarcoma
Aaron Auerbach, MD, MPH
258 Gastrointestinal Stromal Tumor
Aaron Auerbach, MD, MPH
264 Follicular Dendritic Cell Sarcoma
Aaron Auerbach, MD, MPH
272 Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
278 Langerhans Cell Histiocytosis
Guanghua Wang, MD
284 Histiocytic Sarcoma
Nadine Aguilera, MD

LYMPHOMA

292 Introduction to Lymphoma
Mohammad A. Vasef, MD
300 Splenic Marginal Zone Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
308 Hairy Cell Leukemia
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
316 Hairy Cell Leukemia Variant
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
324 Lymphoplasmacytic Lymphoma
Aaron Auerbach, MD, MPH
332 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
340 Follicular Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
348 Primary Splenic Mantle Cell Lymphoma
Mohammad A. Vasef, MD
352 Mantle Cell Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
360 Splenic Diffuse Red Pulp B-Cell Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
366 B-Cell Prolymphocytic Leukemia
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD
368 Diffuse Large B-Cell Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
374 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst
Mohammad A. Vasef, MD
380 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Jeffrey Vos, MD
388 Burkitt Lymphoma
Aaron Auerbach, MD, MPH
396 Classic Hodgkin Lymphoma
Jeffrey Vos, MD
406 Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Aaron Auerbach, MD, MPH
416 Peripheral T-Cell Lymphoma, Unspecified
Mohammad A. Vasef, MD
420 Hepatosplenic T-Cell Lymphoma
Roberto N. Miranda, MD, Francisco Vega, MD, PhD, and L. Jeffrey Medeiros, MD
428 T-Cell Prolymphocytic Leukemia
Mohammad A. Vasef, MD
436 T-Cell Large Granular Lymphocytic Leukemia
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
444 Aggressive NK-Cell Leukemia
Aaron Auerbach, MD, MPH
450 Transformation of Splenic Lymphoma
Nadine Aguilera, MD

LEUKEMIA
454 Acute Myelogenous Leukemia
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD
462 Lymphoblastic Leukemia/Lymphoma
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD


CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES

468 Myeloproliferative Neoplasm Overview
Nadine Aguilera, MD

470 Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Nadine Aguilera, MD

476 Essential Thrombocythemia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH


480 Polycythemia Vera
Guanghua Wang, MD

484 Primary Myelofibrosis
Jeffrey Vos, MD

494 Mastocytosis
Mohammad A. Vasef, MD

500 Chronic Myelomonocytic Leukemia
Mohammad A. Vasef, MD

PLASMA CELL-ASSOCIATED DISORDERS

504 Amyloidosis
Nadine Aguilera, MD
510 Heavy Chain Disease
Aaron Auerbach, MD, MPH
514 Plasma Cell Myeloma/Plasmacytoma
Nadine Aguilera, MD and Aaron Auerbach, MD, MPH

METASTASIS
518 Metastatic Tumors
Ellina Hall, DO and Aaron Auerbach, MD, MPH