Diagnostic Atlas of Non-Neoplastic Lung Disease provides the practicing pathologist with the tools necessary to synthesize diagnoses in biopsy and surgical specimens of non-neoplastic lung disease. Classification of non-neoplastic lung disease has become increasingly complex, especially in diffuse lung diseases where terminology has been changing and clinical and radiologic input is advocated for diagnosis. As a result, general surgical pathologists may feel ill-equipped to interpret such specimens.

In this heavily illustrated and concisely written book, Dr. Katzenstein, a leading authority in pulmonary pathology, has brought a pattern-based approach to formulating diagnoses in non-neoplastic lung diseases with the non-expert pulmonary pathologist in mind. Chapters are organized according to pattern of lung involvement with the idea that once the pattern is recognized the pathologist can easily find examples and review the relevant disease within the corresponding chapter. Filled with tips and key features to navigate differential diagnosis, Diagnostic Atlas of Non-Neoplastic Lung Disease is an indispensable guide for pathologists who encounter non-neoplastic lung specimens in the lab.

Key Features:
* Written by a respected pulmonary pathologist with over 40 years’ experience in the lab
* Over 350 high quality illustrative photomicrographs, many with low and high magnification views
* Emphasizes a pattern-based approach for formulating diagnoses
* Provides helpful tips for establishing diagnosis and avoiding misdiagnosis
* Relevant clinical information including patient demographics, presenting manifestations, and radiographic findings where important for pathologic diagnosis

List of Abbreviations

Preface

Acknowledgments

1. Normal Lung, Common Artifacts, and Incidental Findings

Normal Lung Architecture

Handling of Tissue Specimens

Approach to Diagnosis

Artifacts

Incidental Findings

2. Interstitial Diseases I: Cellular Variants

Cellular Nonspecific Interstitial Pneumonia (NSIP)

Hypersensitivity Pneumonia (HP)

Lymphoid Interstitial Pneumonia (LIP)

Langerhans Cell Histiocytosis (LCH)

Sarcoidosis

Lymphangiomyomatosis (LAM)

Diffuse Meningotheliomatosis

3. Interstitial Diseases II: Fibrotic Variants

Usual Interstitial Pneumonia (UIP)

Fibrotic Nonspecific Interstitial Pneumonia (NSIP)

Scarred Langerhans Cell Histiocytosis (LCH)

Smoking-Related Interstitial Fibrosis (SRIF)

Collagen Vascular Disease-Associated Interstitial Fibrosis

Nonclassifiable Interstitial Fibrosis

Rare, Unproven Entities

Pleuroparenchymal Fibroelastosis (PPFE)

Bronchiolocentric Interstitial Pneumonia

4. Airspace-Predominant Diseases

Organizing Pneumonia (OP)

Eosinophilic Pneumonia

Aspiration Pneumonia

Exogenous Lipoid Pneumonia

Respiratory Bronchiolitis Interstitial Lung Disease/Desquamative Interstitial Pneumonia (RBILD/DIP)

Alveolar Hemorrhage Syndromes

Pulmonary Alveolar Proteinosis (PAP)

Pulmonary Alveolar Microlithiasis (PAM)

5. Diffuse Alveolar Damage, Acute Interstitial Pneumonia

Diffuse Alveolar Damage (DAD)

Acute Interstitial Pneumonia (AIP)

6. Necrotizing Noninfectious Diseases

Granulomatosis With Polyangiitis (GPA)

Eosinophilic Granulomatosis With Polyangiitis (EGPA) (Formerly Churg–Strauss Syndrome) (CSS)

Necrotizing Sarcoid Granulomatosis (NSG)

Bronchocentric Granulomatosis (BCG)

Rheumatoid Nodule

Lymphomatoid Granulomatosis (LYG)

7. Infections I: Nongranulomatous Pneumonias

Viral Pneumonia

Cytomegalovirus Pneumonia (CMV)

Herpes Simplex/Varicella-Zoster Pneumonia

Adenovirus Pneumonia

Measles Pneumonia

Influenza and Other Viral Pneumonias

Fungal Pneumonia

Invasive Aspergillosis/Mucormycosis

Candida Pneumonia

Mycetomas

Pneumocystis Pneumonia

Bacterial Pneumonia

Nocardiosis

Actinomycosis

Legionnaires’ Disease

Rhodococcus Equi Pneumonia/Malakoplakia

8. Infections II: Granulomatous Infections

Evaluation of Necrotizing Granulomas

Histoplasmosis

Cryptococcosis

Coccidioidomycosis

Blastomycosis

Tuberculosis

Nontuberculous Mycobacterial Infections

Dirofilarial Nodule (Dog Heartworm Disease)

9. Pneumoconiosis

Asbestosis

Silicosis

Nodular Silicosis

Acute Silicosis

Mixed Dust Pneumoconiosis

Hard Metal Pneumoconiosis

Miscellaneous Pneumoconiosis

Berylliosis

Talc Pneumoconiosis (Talcosis)

Coal Workers’ Pneumoconiosis (CWP)

Aluminosis

Siderosis

Flock Workers’ Lung

10. Pulmonary Hypertension and Other Noninflammatory Vascular Disorders

Pulmonary Hypertension—General Features

Pulmonary Arterial Hypertension

Primary Pulmonary Hypertension (PPH)

Thrombotic/Thromboembolic Pulmonary Hypertension

Embolic Pulmonary Hypertension

Intravenous Drug Abusers’ Lung (Talc Granulomatosis)

Other Emboli

Other Causes of Pulmonary Arterial Hypertension

Pulmonary Venous Hypertension

Pulmonary Veno-Occlusive Disease (PVOD)

Extrapulmonary Venous Obstruction

Pulmonary Capillary Hemangiomatosis

Pulmonary Emboli

Thromboemboli

Other Emboli

11. Large and Small Airway Diseases

Asthma

Bronchiectasis

Middle Lobe Syndrome

Mucoid Impaction of Bronchi (MIB)

Tracheobronchial Amyloidosis

Tracheobronchopathia Osteochondroplastica (TO)

Respiratory Bronchiolitis (RB)

Follicular Bronchiolitis

Diffuse Panbronchiolitis

Acute Cellular Bronchiolitis

Constrictive Bronchiolitis Obliterans (CBO)

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH)

12. Miscellaneous Nodules, Depositions, and Cysts

Pulmonary Hyalinizing Granuloma (PHG)/Fibrosing Mediastinitis (FM)

Amyloid Nodule (Nodular Amyloidosis)

Nodular Lymphoid Hyperplasia/Inflammatory Pseudotumor

Intraparenchymal Lymph Node

Pulmonary Infarct

Round Atelectasis

Pulmonary Apical Cap

Alveolar Septal Amyloidosis

Metastatic Calcification

Metaplastic Ossification

Blebs, Bullae, Other Cysts, and Pneumothorax-Related Changes

Blebs and Bullae

Other Cysts

Pneumothorax-Related Changes

13. Pediatric Disorders

Pulmonary Sequestration

Intralobar Sequestration

Extralobar Sequestration

Congenital Cystic Adenomatoid Malformation (CCAM)/Congenital Pulmonary Airway Malformation (CPAM)

Bronchogenic Cyst

Congenital Pulmonary Overinflation (Emphysema)

Pulmonary Interstitial Emphysema

Congenital Pulmonary Lymphangiectasis

Diffuse Lymphangiomatosis

Interstitial Lung Disease in Children

Bronchopulmonary Dysplasia (BPD) (Chronic Neonatal Lung Disease)

Chronic Pneumonitis of Infancy (CPI)

Pulmonary Interstitial Glycogenosis (PIG)

Interstitial Pneumonias

Neuroendocrine Cell Hyperplasia of Infancy (NEHI)/Persistent Tachypnea of Infancy

Index