Revised and updated, this edition serves as a reference on the basic mechanisms, physiological consequences, clinical characteristics and management of fever. The book provides analysis of thermoregulation, endogenous and exogenous pyrogens, the role of prostaglandins in fever, the immunological consequences of fever, the cardiovascular alterations that occur during fever, the role of fever in host defense against pathogenic micro-organisms, and the significance of fever pattern in clinical diagnosis. Leading authorities offer guidance on diagnosis and treatment of fever of unknown origin, postoperative fever, drug-induced fever and fever in infants, children, the elderly and the immunosuppressed patient. The pharmacology and clinical use of antipyretics and the influence of fever on pharmacokinetics and pharmacodynamics are also discussed in detail. This second edition is more clinically focused, and features ten more chpaters. Two new categories are included, clinical thermometers and normal temperature, to add greater dimension to the text.