Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event ─apoptosis─ in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers.　

　The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer.

　A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells’ normal state and be used to develop increasingly effective modalities.

Cancer: A Worldwide Menace
Epidemiology
Diagnosis and Pathology
Conclusion
References

Oral Cancer
Key Words
Introduction
Epidemiology
Signs and Symptoms
Sex and Age Distribution
Etiology
Pathology
Staging
Individual Cancers of the Oral Cavity
Conclusion
References

Proliferative and Apoptotic Signaling in Oral Cancer
Key Words
Introduction
Regulation of Cell Homeostasis
Somatic Gene Mutation
Oncogenes and Tumor Suppressors
NF-κB
Serine/Threonine Kinases
Steroid Hormones
Central Role of Caspases
Caspases Inhibitory Proteins
Death Domains
Fas/Fas Ligand
TRAIL and Its Receptors
Conclusion
References

Apoptotic Regulations
Key Words
Introduction
Etymology
Mechanisms of Apoptosis in Cancer
Role of Apoptotic Regulators in Rheumatoid Arthritis (RA)
Role of Apoptotic Regulators in Prostate Carcinoma
Conclusion
References

Dynamics of p53 in Oral Cancer
Key Words
Introduction
Functions and Roles in Causing Disease
p53 as an Oncogene
p53 as a Tumor Suppressor
Mutations in p53
Apoptotic Regulation by p53
Interplay between Survivin and p53
Clinicopathological Significance of p53
Therapeutic Strategies Targeting p53
Conclusion
References

Diagnostic and Therapeutic Potential of Apoptotic Marker
Key Words
Introduction
Apoptotic Markers in Oral Cancer Therapeutics
Apoptotic Markers in Oral Cancer Diagnostics
Conclusion
References

Expression and Regulation of Survivin
Key Words
Introduction
Molecular Organization and Structure of Survivin
Functions of Survivin
Regulation of Survivin
Anti-Apoptotic Network of Survivin
Expression of Survivin in Normal Tissues
Expression of Survivin in Human Cancer
Conclusion
References

Therapeutics of Survivin
Key Words
Introduction
Manipulation of the Survivin Gene
Factors Inducing Survivin Expression
Downregulation of Survivin
Ribozyme-Mediated Degradation of Survivin
Immunotherapy
Therapeutic Biology of Survivin
Survivin-Directed Cancer Therapy
Regulation of Survivin in Head and Neck Squamous Carcinoma
Prognostic and Diagnostic Significance of Survivin
Therapeutic Approach
Survivin for Cancer Immunotherapy
Conclusion
References

Molecular Diagnosis of Oral Cancer
Key Words
Introduction
Molecular Markers for Oral Cancer
Molecular Mechanism of Development of Oral Cancer
The Hallmarks of Oral Cancer
Other Markers
Diagnosis of Oral Squamous Cell Carcinoma
Conclusion
References


Glossary
Index