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Bioinformatics in Cancer and Cancer Therapy |
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Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics; fields of study that have historically existed as mutually exclusive disciplines. Edited by Gavin Gordon, Bioinformatics in Cancer and Cancer Therapy, edited by Gavin Gordon, provides an historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments in order to show how a bioinformatics approach has been used to characterize various cancer-related processes, and to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.
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Preface
Chapter 1: The Emergence of Bioinformatics: Historical Perspective, Quick Overview and Future Trends
Christos A. Ouzounis
Chapter 2: The Statistical Design and Interpretation of Microarray Experiments
Kevin K. Dobbin and Richard M. Simon
Chapter 3: Whole Genome Analysis of Cancer
Steven A. Enkemann, James M. McLoughlin, Eric H. Jensen, and Timothy J. Yeatman
Chapter 4: Bioinformatics Approaches to the Analysis of the Transcriptome of Animal Models of Cancer
Mark J. Hoenerhoff, Aleksandra A. Michalowska, Ting-Hu Qiu, and Jeffery E. Green
Chapter 5: Significance of Aberrant Expression of MicroRNAs in Cancer Cells
George A. Calin, Chang-gong Liu, Manuela Ferracin, Stefano Volinia, Massimo Negrini, and Carlo M. Croce
Chapter 6: Proteomic Methods in Cancer Research
Scot Weinberger and Egisto Boschetti
Chapter 7: Comprehensive Genomic Profiling for Biomarker Discovery for Cancer Detection, Diagnostics and Prognostics
Xiaofeng Zhou, Nagesh P. Rao, Steven W. Cole, and David T. Wong
Chapter 8: Gene Expression Profiling of the Leukemias: Oncogenesis, Drug Responsiveness, and Prediction of Clinical Outcome
Lars Bullinger, Hartmut Dohner, and Jonathan R. Pollack
Chapter 9: Personalized Medicine in the Clinical Management of Colorectal Cancer
Anthony El-Khoueiry and Heinz Josef Lenz
Chapter 10: PIK3CA Gene Alterations in Human Cancers
Sérgia Velho, Carla Oliveira, and Raquel Seruca |
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