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Bioinformatics in Cancer and Cancer Therapy
 

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ÃâÆÇ»ç Humana Press
ÀúÀÚ Gavin J. Gordon
Ãâ°£ÀÏ 2011/11
ÆäÀÌÁö ¼ö 202
Illustrations  
ISBN 1617377589 / 9781617377587
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Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics; fields of study that have historically existed as mutually exclusive disciplines. Edited by Gavin Gordon, Bioinformatics in Cancer and Cancer Therapy, edited by Gavin Gordon, provides an historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments in order to show how a bioinformatics approach has been used to characterize various cancer-related processes, and to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.
 
 
 
Preface


Chapter 1: The Emergence of Bioinformatics: Historical Perspective, Quick Overview and Future Trends


Christos A. Ouzounis




Chapter 2: The Statistical Design and Interpretation of Microarray Experiments


Kevin K. Dobbin and Richard M. Simon




Chapter 3: Whole Genome Analysis of Cancer


Steven A. Enkemann, James M. McLoughlin, Eric H. Jensen, and Timothy J. Yeatman




Chapter 4: Bioinformatics Approaches to the Analysis of the Transcriptome of Animal Models of Cancer


Mark J. Hoenerhoff, Aleksandra A. Michalowska, Ting-Hu Qiu, and Jeffery E. Green




Chapter 5: Significance of Aberrant Expression of MicroRNAs in Cancer Cells


George A. Calin, Chang-gong Liu, Manuela Ferracin, Stefano Volinia, Massimo Negrini, and Carlo M. Croce




Chapter 6: Proteomic Methods in Cancer Research


Scot Weinberger and Egisto Boschetti




Chapter 7: Comprehensive Genomic Profiling for Biomarker Discovery for Cancer Detection, Diagnostics and Prognostics


Xiaofeng Zhou, Nagesh P. Rao, Steven W. Cole, and David T. Wong




Chapter 8: Gene Expression Profiling of the Leukemias: Oncogenesis, Drug Responsiveness, and Prediction of Clinical Outcome


Lars Bullinger, Hartmut Dohner, and Jonathan R. Pollack




Chapter 9: Personalized Medicine in the Clinical Management of Colorectal Cancer


Anthony El-Khoueiry and Heinz Josef Lenz




Chapter 10: PIK3CA Gene Alterations in Human Cancers


Sérgia Velho, Carla Oliveira, and Raquel Seruca
 
 
 
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