Osteoporosis is a widespread disorder with significant worldwide health and economic impact. In the second edition of the highly successful Osteoporosis: Pathophysiology and Clinical Management, new editor Robert A. Adler, MD, uses the same approach as the first edition, pairing a chapter on the basic science of a disorder followed by a chapter on its clinical aspects. Updated and expanded, this second edition includes many new chapters reflecting the growing literature on osteoporosis. New topics cover such areas as methods of bone imaging, screening for osteoporosis, adherence to therapy, and even a novel and exciting chapter on osteoporosis in men, to name just several. In Osteoporosis: Pathophysiology and Clinical Management, Second Edition, leading experts in a variety of fields have once again provided a wealth of invaluable, state-of-the-art information to illuminate the major scientific and clinical aspects of osteoporosis.

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
1 Determinants of Peak Bone Mass Acquisition . . . . . . . . . . . . . . . 1
René Rizzoli and Jean-Philippe Bonjour
2 Bone Mineral Assessment of the Axial Skeleton: Technical Aspects . . . 23
Thomas F. Lang
3 NewImagingTechniques forBone . . . . . . . . . . . . . . . . . . . . 51
Suchandrima Banerjee, Roland Krug, Sven Prevrhal,
and Sharmila Majumdar
4 The Clinical Role of Bone Density Scans in the Diagnosis
and Treatment of Osteoporosis . . . . . . . . . . . . . . . . . . . . . 77
Glen M. Blake
5 Biochemical Markers of Bone Turnover – Basic Biochemistry
and Variability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Markus J. Seibel and Christian Meier
6 BiochemicalMarkers ofBoneTurnover–ClinicalAspects . . . . . . . . 131
Christian Meier, Markus J. Seibel, and Marius E. Kraenzlin
7 BiomechanicsofBone . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
Jacqueline H. Cole and Marjolein C.H. van der Meulen
8 Mechanical Influences on Bone Mass and Morphology . . . . . . . . . . 181
Stefan Judex and Clinton Rubin
9 Exercise in the Prevention of Osteoporosis-Related Fractures . . . . . . . 207
Belinda R. Beck and Kerri M. Winters-Stone
10 The Physiology and Cell Biology of Calcium Transport
in Relation to the Development of Osteoporosis . . . . . . . . . . . . 241
Richard L. Prince
11 Calcium,Bone, andLife . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Robert P. Heaney
12 Basic Aspects of Vitamin D Nutrition . . . . . . . . . . . . . . . . . . . 301
Reinhold Vieth and Gloria Sidhom
13 Clinical Aspects of the Use of Vitamin D and Its Metabolites
in Osteoporosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 319
Ian R. Reid
14 TheBasicBiology ofEstrogenandBone . . . . . . . . . . . . . . . . . 333
Maria Schuller Almeida
15 Estrogens and Estrogen Agonists/Antagonists . . . . . . . . . . . . . . . 351
Robert Lindsay
16 Androgen Action in Bone: Basic Cellular and Molecular Aspects . . . . 359
Kristine M. Wiren
17 AndrogenActions onBone:ClinicalAspects . . . . . . . . . . . . . . . 385
Stefan Goemaere, Guy T’Sjoen, and Jean-Marc Kaufman
18 Salmon Calcitonin: An Update on Its Clinical Utility in Osteoporosis . . 423
Charles H. Chesnut III and Moise Azria
19 Bisphosphonate Mechanisms of Action . . . . . . . . . . . . . . . . . . 443
Alfred A. Reszka
20 Bisphosphonates – Treatment of Osteoporosis . . . . . . . . . . . . . . 469
Ann Cranney
21 BasicAspectsofPTHinSkeletalHealth . . . . . . . . . . . . . . . . . 487
J. M. Hock
22 Clinical Use of Parathyroid Hormone in Osteoporosis . . . . . . . . . . 511
John P. Bilezikian
23 Screening for Osteoporosis . . . . . . . . . . . . . . . . . . . . . . . . . 527
Margaret L. Gourlay
24 Osteoporosis in Men . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545
Robert A. Adler
25 Glucocorticoid-Induced Osteoporosis . . . . . . . . . . . . . . . . . . . 559
Michael Maricic
26 Transplantation Osteoporosis . . . . . . . . . . . . . . . . . . . . . . . 569
Emily Stein and Elizabeth Shane
27 Adherence, Compliance, and Persistence with Osteoporosis Therapies . . 605
Valentina I. Petkov and Melissa I. Williams
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 621