Advances in Surgical Pathology: Gastric Cancer provides a concise, updated review of the pathological characteristics of gastric cancer, with an emphasis on exploring practical issues and recent developments. The book features current and emerging concepts in the field of gastric cancer, a disease whose management requires a multidisciplinary approach in which pathology plays a key role. Its six sections cover the essential histopathology of gastric cancer as well as related topics such as imaging evaluation, molecular diagnosis, and personalized treatment, among other areas of interest. Individual chapters written by international experts in the fields of pathology, gastrointestinal medical oncology, cancer epidemiology, and gastrointestinal radiology, address the fundamental issues surrounding gastric cancer, including its epidemiology, basic diagnostic features, differential diagnoses, pitfalls and complications, and treatments. Endoscopic evaluation and histology correlation are emphasized. The screening, clinical management, and treatment of gastric cancer are summarized in related book sections. Recent findings regarding the roles of immunohistochemistry and molecular testing in the diagnosis, prognosis, and personalized treatment of gastric cancer are also reviewed. The book also includes current knowledge regarding the molecular alteration of gastric cancer carcinogenesis and its impact on patient care.

SECTION I. Introduction

1 Introduction to the Normal Histology and Physiology of the Stomach
William Payne, and Dongfeng Tan
2 Epidemiology of Gastric Carcinoma
Woo Ho Kim
3 Helicobacter pylori and Gastric Neoplasms
Antonia R. Sepulveda, and Abha Goyal
4 Epstein-Barr Virus and Gastric carcinoma
Masashi Fukayama, Aya Shinozaki, and Rumi Hino

SECTION II. Histopathology

5 Gastric Carcinoma: Classifications and Morphologic Variants
Do Youn Park, Hye Seung Han, and Gregory Y. Lauwers
6 Early and Advanced Gastric Carcinomas
Shinichi Ban
7 Neuroendocrine Tumors and Nonneoplastic Neuroendocrine
Cell Changes
Guido Rindi, and Enrico Solcia
8 Secondary Tumors
Mikhail Lisovsky, and Amitabh Srivastava
9 Gastrointestinal Stromal Tumor
Min En Nga, and Amitabh Srivastava
10 Primary Gastric Lymphoma
X. Frank Zhao, and Sanford A. Stass

SECTION III. Endoscopy and Emerging Techniques

11 Correlation of Endoscopy with Histopathology in Gastric Neoplasm
Michio Shimizu, Hiroto Kita, and Koji Nagata
12 New Imaging Techniques for the Diagnosis of Early Gastric Cancer and Premalignant Lesions
Thomas Paulraj Thamboo, Zhiwei Huang, and Ming Teh

SECTION IV. Molecular Pathology

13 Molecular Pathology of Gastric Neoplasms
Shengle Zhang
14 Epigenetic Abnormalities of Gastric Cancer
Annie On On Chan, and Asif Rashid
15 Molecular Biomarkers of Gastric Adenocarcinoma
John J. Liang, and Dongfeng Tan
16 Proteomics, Morphoproteomics, and Targeted Therapy of Gastric Carcinoma
Wei Feng, and Dongfeng Tan
17 Molecular Prognostic Markers of Gastric Cancer
Mahmoud Goodarzi, and Dongfeng Tan

SECTION V. Staging

18 TNM and Concerns in the Staging of Gastric Cancer
Dongfeng Tan
19 New Staging System for Gastric Cancer
Madhavi Patnana, and Raghunandan Vikram

SECTION VI. Preneoplastic and Preinvasive Lesions

20 Chronic Gastritis and Gastric Precancerous Conditions
Massimo Rugge, Donato Nitti, Gregory Y. Lauwers, and David Y. Graham
21 Gastric Polyps
Richard H. Lash, Shawn Kinsey, Robert M. Genta, and Gregory Y. Lauwers
22 Gastric Dysplasia
Mikhail Lisovsky, and Gregory Y. Lauwers